Solomkin,mdb intraabdominal infections are generally the result of invasion and multiplication of enteric bacteria in the wall of a hollow viscus or beyond. Mar, 2014 this video is part of the mount sinai hospitaluniversity health network antimicrobial stewardship program with suppo. I would like to welcome you to this program titled, treatment of complicated intra abdominal infections. This helps you give your presentation on symptoms and signs in acute abdominal pain in a conference, a school lecture, a business proposal, in a webinar and. Pathophysiology, intraabdominal infections mycybercollege. Clinical cases study for intraabdominal infections 1. The surgical infection society and infectious diseases society of america recently updated recommendations for diagnosis and treatment of intra abdominal infections.
Ppt intraabdominal infection powerpoint presentation free to download id. Intraabdominal candidiasis iac is poorly understood compared to candidemia. Intraabdominal infections pharmacotherapy principles. Determine goals of therapy such as correction of the intraabdominal disease process and drainage of purulent collections and resolution of infection without major organ system complications. In complicated intra abdominal infections, the infection progresses from a single organ and affects the peritoneum, causing intra abdominal abscesses or diffuse peritonitis. Powerpoint is the worlds most popular presentation software which can let you create professional symptoms and signs in acute abdominal pain powerpoint presentation easily and in no time. Pdf 20 wses guidelines for management of intraabdominal.
Risk factors for mortality were evaluated using multivariable logistic regression. Displaying powerpoint presentation on intraabdominal infections caregate available to view or download. Intra abdominal infections usually arise after a breach in the intrinsic mucosal defense barrier that allows normal bowel flora to inoculate the abdominal cavity. Intraabdominal infection iai is a broad term that encompasses a number of infectious processes. Sameh ahmad muhamad abdelghany lecturer of clinical pharmacology mansura faculty of medicine 2. Well defined evidencebased recommendations for intra abdominal infections treatment are partially lacking because of the limited number of randomizedcontrolled trials. Iai are classified as uncomplicated or complicated based on the extent of infection. May 14, 2014 the ciaow study complicated intra abdominal infections worldwide observational study is a multicenter observational study underwent in 68 medical institutions worldwide during a sixmonth study period october 2012march 20. Most intraabdominal infections are secondary infections that are polymicrobial and. Early or diffuse infection results in localized or generalized peritonitis. These organisms play a central role in most intra abdominal abscesses. This helps you give your presentation on symptoms and signs in acute abdominal pain in a conference, a school lecture, a business proposal, in a webinar and business and professional.
Peritonitis is subdivided into primary, secondary, and tertiary varieties. Fig 1 multiple dilated bowel loops of small bowel are seen in the pelvis, with extensive. The precise microbiological spectrum depends on the precise gastrointestinal source ie, small versus large bowel. Intra abdominal infections are the second leading cause of infectious death in the intensive care unit. Infection signs such as fever and elevated white blood cell counts wbcs are often present. Evaluation of a short course of antimicrobial therapy for complicated intraabdominal infections in critically ill surgical patients 2017. Sep 15, 2010 intra abdominal infections are the second most common cause of infectious mortality in intensive care units. Psapvii infectious diseases 181 intraabdominal infections agreed on clinically.
It is the second most commonly identified cause of severe sepsis in the intensive care unit icu. Intraabdominal infections are among the most common infections in general. A 10 year surveillance for antimicrobial susceptibility of. Recent studies have associated severe intra abdominal infection with a significant mortality rate. Intraabdominal infection iai describes a diverse set of diseases.
Recent guidelines from the infectious diseases society of america suggest that a compli cated intraabdominal infection is an intraabdominal infection coupled with any one of the following indi. Clinical failure complicated urinary tract infections cuti. Intraabdominal infections with range of spectrum of diseases, from simple peritonitis or appendicitis to complicated diverticulosis or intestinal. Updated results in complicated intraabdominal infections ppt. Both primary and secondary peritonitis have an inhospital mortality rate of approximately 20%. Patients with intra abdominal infections typically present with abdominal pain and some degree of gi dysfunction e. Administration of an antibiotic to which the organism is sensitive. Symptoms and signs in acute abdominal pain powerpoint.
Oct 29, 20 pathophysiology, intraabdominal infections mycybercollege. Mar 28, 2018 11 git microflora intra abdominal infections result in 2 major clinical manifestations i. A focus on intraabdominal infections pubmed central pmc. Pathophysiology, intraabdominal infections youtube. Fragilis, other git flora female genital tract infections vulva abscesses pepto streptococci others tuboovarian pelvic infections p. When the infection extends into the peritoneal cavity or another normally sterile region of the abdominal cavity. Peritonitis and intraabdominal abscesses are much feared because of the high frequency of associated septic shock and multisystem organ failure.
Clinical response and mortality in tigecycline complicated. Updated guideline on diagnosis and treatment of intra. Intra abdominal infections liver abscess mixed anaerobes 4090 facultative organisms abdominal abscesses b. I am dr joseph solomkin, emeritus professor of surgery at the university of cincinnati in ohio. Practice guidelines are systematically developed statements to assist practitioners and patients in making decisions about appropriate health care for specific clinical circumstances. Determine goals of therapy such as correction of the intra abdominal disease process and drainage of purulent collections and resolution of infection without major organ system complications.
Find powerpoint presentations and slides using the power of, find free presentations research about guidelines intraabdominal infection ppt. A free powerpoint ppt presentation displayed as a flash slide show on id. The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intraabdominal infections. Well defined evidencebased recommendations for intraabdominal infections treatment are partially lacking because of the limited number of randomizedcontrolled trials. Anaerobic infections, intraabdominal quick medical. Idsa guidelines diagnosis and management of complicated intraabdominal. Intra abdominal infections are the second most com mon cause of infectious mortality in intensive care units. Many pathogens implicated in these infections have developed resistance to standard antibiotics, thereby limiting treatment options. Complicated intra abdominal infection, which extends into the peritoneal space, is. Intra abdominal infection is the property of its rightful owner. They include both inflammation of single organs and any sort.
Right lateral paracolic right medial paracolic gutter left medial. Intra abdominal infections include a wide spectrum of conditions from uncomplicated appendicitis to faecal peritonitis. Daniel rubin, phd division of biometrics iv, office of. Intraabdominal infection guidelines 2010 slideshare. Attributes of good guidelines include validity, reliability, reproducibility, clinical applicability, clinical flexibility, clarity, multidisciplinary process. Mar 14, 2014 powerpoint is the worlds most popular presentation software which can let you create professional symptoms and signs in acute abdominal pain powerpoint presentation easily and in no time.
We investigated clinical failure and mortality in phase 3 and 4 complicated skin and softtissue infection cssti and complicated intraabdominal infection ciai tigecycline trials using descriptive analyses of a blinded adjudication of mortality and. Fig 1 multiple dilated bowel loops of small bowel are seen in the pelvis. In complicated intraabdominal infections, the infection progresses from a single organ and affects the peritoneum, causing intraabdominal abscesses or diffuse peritonitis. Infectious diseases society of america guidelines for the selection of antiinfective agents for complicated intra abdominal infections. This video is part of the mount sinai hospitaluniversity health network antimicrobial stewardship program with suppo. Results of a randomized trial comparing sequential intravenousoral treatment with ciprofloxacin plus metronidazole to imipenemcilastatin for intra abdominal infections. Secondary intra abdominal infections are usually caused by a mixture of bacteria, including enteric gramnegative bacilli and anaerobes, which enhance the pathogenic potential of the bacteria. Novel approaches to restoration of a functional gastrointestinal tract have emerged as alternatives to more invasive surgery. Which medication is dispensed as 2 vials that are drawn into 1 syringe and administered as a bolus. Peritonitis and intraabdominal abscess principles and. The aerobic and anaerobic microbiology of intraabdominal infections associated with diverticulitis was studied in 110 specimens from the peritoneal cavity after intestinal perforation and in 22 specimens from abdominal abscesses.
Intra abdominal infection iai, also spelled intraabdominal is a group of infections that occur within the abdominal cavity. Primary peritonitis is a monomicrobial infection in which the integrity of the gastrointestinal tract has not been violated. The general principle underlying antimicrobial therapy for patients who have intra abdominal infections is to use agents effective against the aerobicfacultative anaerobic gramnegative bacilli, aerobic grampositive cocci, and obligate anaerobic organisms commonly encountered with these infections. An unusual case of intraabdominal air gastroenterology. Ppt intraabdominal infections powerpoint presentation. Treatment of complicated intraabdominal infections transcript. For peritonitis, early and effective iv fluid resuscitation and electrolyte replacement therapy are essential. Chief complain 4 amy belly hurts so bad i can barely move. Uncomplicated abdominal infections involve intramural inflammation of the gastrointestinal.
An imbalance in allcause mortality was noted in tigecycline phase 3 and 4 comparative clinical trials across all studied indications. Genitourinary infections abscess forms as sequelae of generalized peritonitis in 33% of cases intraabdominal abscess forms adjacent to diseased viscus eg, perforated appendicitis or as a result of external contamination subphrenic abscess broadly classified based on anatomic location. Mar 14, 2014 powerpoint is the worlds most popular presentation software which can let you create professional abdominal painan overview powerpoint presentation easily and in no time. Guidelines intraabdominal infection ppt xpowerpoint. He also noted that his skin had become yellow and his urine teacolored. Complicated intraabdominal infections are an important cause of morbidity and are frequently associated with poor prognosis, particularly in higher risk patients. A 48 year old woman attended the emergency department with a sudden onset of severe abdominal pain, worsening over the few hours before presentation. He complained of nausea, abdominal fullness, and fever. Intraabdominal infections represent a wide variety of pathological conditions that involve lesions of all the intraabdominal organs. I would like to welcome you to this program titled, treatment of complicated intraabdominal infections. Ppt intraabdominal infection powerpoint presentation.
Late and localized infections produces an intraabdominal abscess. We described the clinical characteristics, microbiology, treatment and outcomes of iac, and identified risk factors for mortality. Managing intraabdominal infections in the icu youtube. Peritonitis and intra abdominal abscesses are much feared because of the high frequency of associated septic shock and multisystem organ failure. From 2002 to 2011, the minimum inhibitory concentrations mics of 12 antibiotics against 3074 e. Intraabdominal infections caregate powerpoint presentation. Complicated intra abdominal infection, which extends. Secondary intraabdominal infections are usually caused by a mixture of bacteria, including enteric gramnegative bacilli and anaerobes, which enhance the pathogenic potential of the bacteria.
The aerobic and anaerobic microbiology of intra abdominal infections associated with diverticulitis was studied in 110 specimens from the peritoneal cavity after intestinal perforation and in 22 specimens from abdominal abscesses. We performed a retrospective study of adults diagnosed with iac at our center in 201220. Two general types of intraabdominal infections are discussed throughout this chapter. Apr 24, 2018 clinical cases study for intraabdominal infections 1. Intra abdominal infections are common in clinical practice and comprise a wide variety of clinical presentations and differing sources of infection. Ppt anaerobic infections powerpoint presentation free to. Ppt anaerobic infections powerpoint presentation free. Intra abdominal infection results from entry of bacteria into the peritoneal. These organisms play a central role in most intraabdominal abscesses. Percutaneously drained intraabdominal infections do not require longer duration of antimicrobial therapy. They may also participate in hepatic abscess and cholecystitis.
Complicated intraabdominal infections ciais are challenging and common in clinical practice and universal reason for hospital stay, often caused by a mixture of aerobic and anaerobic bacteria, increase the risk of mortality. View and download powerpoint presentations on guidelines intraabdominal infection ppt. This helps you give your presentation on abdominal painan overview in a conference, a school lecture, a business proposal, in a webinar and business and professional. The objective of this study was to investigate the susceptibility of hospitalassociated ha and communityassociated ca escherichia coli and klebsiella pneumoniae isolated from patients with intraabdominal infections iais in china. Results of a randomized trial comparing sequential intravenousoral treatment with ciprofloxacin plus metronidazole to imipenemcilastatin for intraabdominal infections. Intraabdominal infections are the second leading cause of infectious death in the intensive care unit. Generally, an ebook can be downloaded in five minutes or less.
Intraabdominal infections iais are those contained within the peritoneal cavity or retroperitoneal space. If so, share your ppt presentation slides online with. Late and localized infections produces an intra abdominal abscess. This helps you give your presentation on abdominal painan overview in a conference, a school lecture, a business proposal, in a webinar and business and professional representations.
Download intraabdominal infections caregate ppt for free. Complicated intraabdominal infection ciai generally results from perforation or necrosis of the gastrointestinal tract and release of bacteria into the peritoneal and retroperitoneal space. We investigated clinical failure and mortality in phase 3 and 4 complicated skin and softtissue infection cssti and complicated intra abdominal infection ciai tigecycline trials using descriptive analyses of a blinded adjudication of mortality and. Feb 23, 2011 intra abdominal infection iai is an important cause of morbidity and mortality. Treatment of complicated intraabdominal infections. Joining me today is dr john mazuski, professor of surgery at washington university in st louis. Anaerobic bacteria only were isolated from 17 15% of the peritoneal specimens, aerobic bacteria only from 12 11% and mixed aerobic and anaerobic flora from 81 74%. Ppt intraabdominal infections powerpoint presentation, free.
Aerobic and anaerobic microbiology in intraabdominal. Intraabdominal infections pharmacotherapy quick guide. Intra abdominal infections represent a wide variety of pathological conditions that involve lesions of all the intra abdominal organs. Treatment a change in antimicrobial therapy should be considered in patients with hospitalacquired infections who are already on antimicrobials. A 52yearold man with a history of hypertension and diabetes mellitus was admitted because of right upper abdominal pain of 3 days duration. She underwent a computed tomography scan for further assessment. Intraabdominal infections usually arise after a breach in the intrinsic mucosal defense barrier that allows normal bowel flora to inoculate the abdominal cavity. Intra abdominal infections iais are those contained within the peritoneal cavity or retroperitoneal space.
Most of the complicated intraabdominal infections treated by surgeons involve peritonitis or intraabdominal abscesses. Intraabdominal infections are those contained within the peritoneum or retroperitoneal space. Definition and classification of intraabdominal infections. Aug 30, 2018 a 48 year old woman attended the emergency department with a sudden onset of severe abdominal pain, worsening over the few hours before presentation. Most intraabdominal infections are secondary infections that are polymicrobial and are caused by a defect in the gastrointestinal gi tract that must be treated by surgical drainage, resection, andor repair. An axial section through the pelvis is included fig 1. Microbial contamination of the peritoneal cavity is termed, and is classified according to etiology.
339 205 1492 670 870 235 1406 748 1671 555 206 909 1004 1232 1371 628 1187 55 1585 344 1063 605 882 126 1017 1447 1460 787